| Minggu, September 12, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Birmingham | v | Liverpool | St Andrews Stadium | ||
| Senin, September 13, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Stoke City | v | Aston Villa | Britannia Stadium | ||
| Sabtu, September 18, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Stoke City | v | West Ham United | Britannia Stadium | ||
| Aston Villa | v | Bolton Wanderers | Villa Park | ||
| Blackburn Rovers | v | Fulham | Ewood Park | ||
| Everton | v | Newcastle United | Goodison Park | ||
| Tottenham Hotspur | v | Wolverhampton Wanderers | White Hart Lane | ||
| West Bromwich Albion | v | Birmingham | The Hawthorns | ||
| Sunderland | v | Arsenal | Stadium of Light | ||
| Minggu, September 19, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Manchester United | v | Liverpool | Old Trafford | ||
| Wigan Athletic | v | Manchester City | DW Stadium | ||
| Chelsea | v | Blackpool | Stamford Bridge | ||
| Sabtu, September 25, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Manchester City | v | Chelsea | City of Manchester Stadium | ||
| Arsenal | v | West Bromwich Albion | Emirates Stadium | ||
| Birmingham | v | Wigan Athletic | St Andrews Stadium | ||
| Blackpool | v | Blackburn Rovers | Bloomfield Road | ||
| Fulham | v | Everton | Craven Cottage | ||
| Liverpool | v | Sunderland | Anfield | ||
| West Ham United | v | Tottenham Hotspur | Upton Park | ||
| Minggu, September 26, 2010 | |||||
| Kandang | Tandang | STADIUN | |||
| Bolton Wanderers | v | Manchester United | Reebok Stadium | ||
| Wolverhampton Wanderers | v | Aston Villa | Molineux Stadium | ||
| Newcastle United | v | Stoke City | St James' Park | ||